Estrogen receptors (ER) and progesterone receptors (PR; also called PgR) may be found in breast cancer cells. This suggests that the cancer cells, like normal breast cells, may receive signals from estrogen that could promote their growth.
Estrogen receptor-positive (ER-positive) breast cancer is the most common type of breast cancer diagnosed today.
In the case of estrogen receptor-negative breast cancer, or ER-negative breast cancer, the cells do not have hormone receptors for estrogen. Cancer cells with these receptors depend on estrogen and related hormones, such as progesterone, to grow. Hormonal therapy is only used for breast cancer that is hormone receptor positive. ER-positive: Breast cancers that have estrogen receptors are called ER-positive (or ER+) cancers. Hormone status of breast cancers includes: Estrogen receptor (ER) positive.
Treatments that stop these hormones from attaching to these receptors are called hormone or endocrine therapy. What are estrogen and progesterone receptors? This means that the cancer cells have receptors for estrogen (ER+), progesterone (PR+) or both.
A cancer is called estrogen-receptor-positive (or ER+) if it has receptors for estrogen. When cancer cells have these receptors, the hormones can attach to them and help them grow. The cells of this type of breast cancer have receptors that allow them to use the hormone estrogen to grow. Most breast cancers -- about 70% -- are sensitive to the hormones estrogen or progesterone. Hormone therapy can reach cancer cells almost anywhere in the body and not just in the breast. Treatment with anti-estrogen hormone (endocrine) therapy can block the growth of the cancer cells. If your breast cancer has a significant number of receptors for either estrogen or progesterone, it’s considered hormone-receptor positive.
According to the American Cancer Society, about 2 …
Some types of cancerous, or malignant, breast tumors have cell receptors to which the hormone estrogen attaches, stimulating the cells to grow. Hormone receptors are proteins — found in and on breast cells — that pick up hormone signals telling the cells to grow.
The breast cancer cells have receptors (proteins) that attach to estrogen and progesterone, which helps them grow. These tumors have a sort of biological on-off switch called a hormone receptor. PR-positive: Breast cancers with progesterone receptors are called PR-positive (or PR+) cancers. Hormone receptor-positive: If …
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