Protein Names. In response to insulin binding, PKB/AKT phosphorylates GSK-3β on serine 9, which prevents GSK-3β from phosphorylating glycogen synthase. A model for GSK‐3β regulation of dynein‐dependent retrograde organelle transport. Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues around Ser9 of human GSK-3β.
Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser9 of human GSK-3β. B) When the cell is stimulated by insulin, PI3K/AKT signaling is initiated and GSK‐3β is shut off. Gene Synonyms.
Protein expression was examined after continuous stretch for 24 h; 20 µM of LY294002 (2 µl/well) was added to the cells 2 h before initiation of stretching. Glycogen Synthase Kinase 3β (GSK-3β) is a unique serine/threonine kinase that is inactivated by phosphorylation. Supplier also known as
Gene Synonyms. Protein Names.
D3DN89, P49841, Q9BWH3, Q9UL47.
UniProt Code History. A) In control cells, GSK‐3β can phosphorylate IC at S87/T88, decreasing its interaction with Ndel1 and reducing dynein motility toward microtubule minus ends. UniProt Code History GSK-3β, glycogen synthase kinase 3β; p, phosphorylated. Protein Names. Glycogen synthase kinase-3β (GSK-3β) has emerged as a critical factor in several pathways involved in hippocampal neuronal maintenance and function. Glycogen synthase kinase-3 beta, Serine/threonine-protein kinase GSK3B, GSK3B_HUMAN. GSK-3β by inhibiting Wnt signaling, and the activation of GSK-3β is closely associated with amyloid β depos-ition [40, 45]. GSK3B. Effect of PI3K/Akt signaling inhibitor LY294002 on the levels of Akt, p-Akt, GSK-3β and p-GSK-3β in rat L6 myoblasts. Unphosphorylated glycogen synthase is active and able to synthesize glycogen. Glycogen synthase kinase 3 (GSK ‐3) has been linked to regulation of kinesin‐dependent axonal transport in squid and flies, and to indirect regulation of cytoplasmic dynein.We have now found evidence for direct regulation of dynein by mammalian GSK ‐3β in both neurons and non‐neuronal cells. Glycogen synthase kinase-3 beta, Serine/threonine-protein kinase GSK3B, GSK3B_HUMAN. Figure 8. Glycogen synthase kinase-3 beta, Serine/threonine-protein kinase GSK3B, GSK3B_HUMAN. Supplier also known as The two isoforms, GSK-3α and GSK-3β, have both been suggested to play a detrimental role in neuronal death.
Antibodies are purified by protein A and peptide affinity chromatography. UniProt Code History. GSK ‐3β coprecipitates with and phosphorylates mammalian dynein. In the present study, we detected the acti-vation of GSK-3β in rTg4510 mice fed the control and doxycycline diets, and a positive correlation was observed between hp-tau accumulation and GSK-3β … Glycogen synthase kinase-3 (GSK-3) dysregulation has been implicated in nigral dopaminergic neurodegeneration, one of the main pathological features of Parkinson’s disease (PD). Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to the sequence of human GSK-3β. D3DN89, P49841, Q9BWH3, Q9UL47. GSK3B.
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