Okadaic acid (OA) and its analogs, the dinophysistoxins, are potent inhibitors of protein phosphatases 1 and 2A. One of the primary causes of diarrhetic shellfish poisoning, okadaic acid is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells. 805.0 Da. These tumor-promoting properties and its ability to significantly increase protein phosphorylation make okadaic acid a very useful tool for studying cellular processes that are regulated by … Cited in 11 publications. On addition of OKA, it will bind to the aptamer … Okadaic acid (OKA), a marine toxin produced by dinoflagellates, is responsible for most human diarrhetic shellfish poisoning-associated health disorders. Size: 100 µg. Safety Data Sheet: Okadaic acid Identification of the substance/mixture and of the Company Product identifiers Product name 13Okadaic acid Formula C44H68O Product Code OA RTECS AA8227800 CAS # 78111-17-8 Molecular weight 805 EC Number # 616-589-8 Intended uses of the substance or mixture and uses advised against Intended use Uses advised against:
A product of dinoflagellate metabolism, okadaic acid is the causative agent of diarrhetic shellfish poisoning. CAS 78111-17-8, is a 250 µM solution of Okadaic Acid in DMSO. Qty-+ Add to Cart. Non-phorbol type tumor promoter. Description. Particularly, a concentration of 150 nM of 19-epi-okadaic acid was required to induce the same neurotoxic effects observed at 0.5 nM OA or at 2.5 nM DTX-1 treatments . Okadaic acid has also been described as a non-TPA type potent tumor promoter (4). Okadaic Acid Stimulates Complexed and Chromatin- Associated pp33 and pp15 Phosphorylation Quiescent [“PIphosphate-labeled cells were stimulated with, lanes 2, 1 pM okadaic acid; lanes 3,100 nM TPA; lanes 4,100 nM TPA + 1 hM okadaic acid. However, other OA analogs such as 19-epi-okadaic acid or belizeanic acid were recently found to induce lower inhibitory potencies, mainly related to PP1 [18,19]. This action is well known to cause diarrhea and gastrointestinal symptons when the toxins reach the digestive tract by ingestion of mollusks.
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Okadaic acid, C 44 H 68 O 13, is a toxin produced by several species of dinoflagellates, and is known to accumulate in both marine sponges and shellfish. Potent inhibitor of protein phosphatase 1 (IC50 = … Join researchers using our high quality biochemicals. $165. However, within 90-120 min treated cells rounded up and detached from the monolayer, regardless of whether they were in inter-phase or mitosis. A competitive displacement assay for OKA is described here.
Okadaic acid, PP1 and PP2A inhibitor (CAS 78111-17-8). Abstract The dinoflagellate Dinophysis acuta has been associated with various incidents of diarrhetic shellfish poisoning. Okadaic acid has been frequently used to enhance the phosphorylation of MST1 and MST2 and to trigger the activation of the Hippo pathway. Okadaic acid, a specific protein phosphatase inhibitor, is currently used in models of Alzheimer's research to increase the degree of phosphorylation of various proteins, such as the microtubule-associated protein tau. Catalog # 27047. CAS Registry # 78111-17-8. However other components of the Hippo pathway could also be targets of okadaic acid. Okadaic acid (OA) is a marine toxin, a tumor promoter and an inducer of apoptosis. Okadaic Acid . okadaic acid (0.5-1.0 /iM), mitosis was blocked within 30-60 min of treatment. A less well‐known effect of these group of toxins is their effect in the cytoskeleton. Okadaic acid is a toxin that accumulates in bivalves and causes diarrhetic shellfish poisoning. Esta página se editó por última vez el 18 abr 2020 a las 17:59. An OKA-binding aptamer was truncated with two sequences, one labeled with 6-carboxyfluorescein (FAM), and one with a quencher.
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