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It is implicated in Alzheimer's disease and cardiovascular disease.
This study was ap- proved by the Institutional Review Board of Bundang Jaesang Hospital. Background Information for Apolipoprotein E (APOE) Genotyping, Alzheimer Disease Risk Characteristics: Alzheimer disease (AD), the most common cause of dementia, is characterized by progressive cognitive decline including memory, problem-solving skills, multi-step tasks, planning, and changes in personality. In humans, apolipoprotein E (apoE) is a polymorphic protein of which three common isoforms can be distinguished, designated apoE2, apoE3, and apoE4.
It is an important regulator of blood levels of both cholesterol and triglycerides. and plays an integral part in the transport of these fats in the body.
In the circulation, it is present as part of several classes of lipoprotein particles, including chylomicron remnants, VLDL, IDL, and some HDL.. APOE interacts significantly with the low-density lipoprotein receptor, which is essential for the normal processing of triglyceride-ric Apolipoprotein E (apoE) is a key protein linked to the pathogenesis of Alzheimer’s disease (AD) beyond its central roles in lipid metabolism. 1962-19681992 Printed in U. S. A. Among the three human APOE gene alleles, APOE4 is the strongest genetic risk factor for AD, while APOE2 is protective. APOE belongs to a family of fat-binding proteins called apolipoproteins. THE JOURNAL OF BIOLOGICAL CHEMISTRY 0 1992 by The American Society for Biochemistry and Molecular Biology, Inc. Vol. Apolipoprotein E (ApoE) plays a major role in the metabolism of dietary fat. APOE is a glycoprotein related to the the metabolism of … Quantitative analysis of apolipoprotein B and E Apolipoprotein B Human ELISA kit and Apolipoprotein E Human ELISA kit (Abcam, United States) were used for serum analysis, following the kit protocol precisely.
Variants of apolipoprotein E have been studied extensively as risk factors for many different conditions.
There are three different types of the ApoE gene, called alleles; E2, E3, and E4.
This genetic variation is associated with different plasma lipoprotein levels, different response to diet and lipid-lowering therapy, and a variable ri … This study provides the first systematic investigation of gait characteristics relationship with relevant demographic, physical, genetic (Apolipoprotein E genotype), and health risk factors in non-demented older adults during a cognitive-load dual task walking condition. Apolipoprotein E is a protein involved in the metabolism of fats in the body.
patients' hematological characteristics. APOE has three isoforms (E2, E3, and Ε4), distinguished by its lipid-binding activity.1 The most common isoform, E3, is considered the normal form. ApoE2 homozygote glomerulopathy has been found in individuals expressing homozygous apoE2/2. 261, No.
In this report, we examine the role of APOE genotypes on the effect of treatment … Apolipoprotein E (APOE) polymorphism is one of the most important genetic markers for CAD and has also been related to some kinds of dementia (4,5) and resistance to infections by some viruses (4-8). The Functional Characteristics of a Human Apolipoprotein E Variant (Cysteine at Residue 142) May Explain Its Association with Dominant Expression of Type I11 Hyperlipoproteinemia" The brachiocephalic arteries of fat-fed apolipoprotein E knockout mice develop plaques that frequently rupture and form luminal thromboses. Of the glomerular disorders that occur due to apolipoprotein E (apoE) mutations, apoE2 homozygote glomerulopathy and lipoprotein glomerulopathy (LPG) have been characterized. This was characterized histologically by glomerulosclerosis with marked infiltration of foam cells derived from macrophages, … Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease. For example, APOE alleles have been shown to influence the risk of cardiovascular diseases. Apolipoprotein E It also helps catabolize (break down) triglycerides.
Inside the brain, APOE helps to clear beta-amyloid, a component of plaques. Outside the brain, APOE4 can increase the risk of atherosclerosis (i.e., hardening of the arteries) and stroke , which may explain why APOE4 is a risk factor for vascular causes of cognitive impairment and dementia . A subset of the TEAM‐AD trial participants (N = 415) also participated in a DNA Bank substudy that stored blood DNA for determination of apolipoprotein E (APOE) genotypes 2, 3. ... Alzheimer's disease characteristics. The lipoprotein apolipoprotein E (APOE) is mainly produced in the liver and is involved in cholesterol metabolism.
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