Die Phosphorylierung bestimmter Zielproteine durch GSK-3 inhibiert diese in der Regel. The beta-isoform of glycogen synthase kinase-3 (GSK3 beta) isolated from rabbit skeletal muscle was inactivated 90-95% following incubation with MgATP and either MAP kinase-activated protein kinase-1 (MAPKAP kinase-1, also termed RSK-2) or p70 S6 kinase (p70S6K), and re-activated with protein phosphatase 2A. Wang QM(1), Fiol CJ, DePaoli-Roach AA, Roach PJ. Glycogen synthase kinase 3 (GSK3) was identified over 20 years ago as a protein kinase that phosphorylated and inhibited glycogen synthase [1], the enzyme that catalyzes the transfer of glucose from UDPG to glycogen.Subsequently, two separate isoforms were cloned, termed GSK3α and GSK3β [2].
Glycogen synthase kinase-3 (GSK3) is also a serine/threonine protein kinase that has been recently characterized as a mediator of inflammation. Author information: (1)Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202-5122.
Introduction. Philip Cohen, Sheelagh Frame, in Handbook of Cell Signaling, 2003.
Glykogensynthase-Kinase 3 (GSK-3) ist eine Serin/Threonin-Protein-Kinase, es handelt sich also um ein Protein, welches selektiv Phosphat-Reste an die Serin- und Threonin-Reste anderer Proteine anbringt (in diesem Fall handelt es sich um die Glykogensynthase). Glycogen synthase kinase 3 is a serine/threonine protein kinase that mediates the addition of phosphate molecules onto serine and threonine amino acid residues.
... inhibited by glycogen synthase kinase-3 beta and facilitated by In mammals GSK-3 is encoded by two paralogous genes, GSK-3 alpha (GSK3A) and GSK-3 beta (GSK3B).
GSK-3 has recently been the subject of much research be… Abnormal regulation and expression of GSK3β is associated with an increased susceptibility towards bipolar disorder.
gical effects of Glycogen synthase kinase 3 specific inhibitor ... protein kinase A and glycogen synthase kinase-3 alters DNA-binding affinity, conformation, and increases net charge. Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation. Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene. GSK3 beta has now been shown to induce activation of the mitogen-activated protein kinase kinase kinase MEKK1 and thereby to promote signaling by the stress-activated protein kinase pathway.
Bio-chemistry37,3795–3809.
Abstract. Glycogen synthase kinase 3beta (GSK3 beta) is implicated in many biological events, including embryonic development, cell differentiation, apoptosis, and insulin response. First discovered in 1980 as a regulatory kinase for its namesake, Glycogen synthase, GSK-3 has since been identified as a kinase for over 100 different proteins in a variety of different pathways.
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